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Bravo capsule system optimizes intragastric pH monitoring over prolonged time: Effects of ghrelin on gastric acid and hormone secretion in the rat
Karolinska Institute.
Karolinska Institute.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
GlaxoSmithKline Inc.
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2008 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, Vol. 14, no 40, 6180-6187 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To evaluate measurements of intragastric pH with the Bravo capsule system over a prolonged time.

Methods: A Bravo capsule was placed inside the rat gastric body and pH was studied for periods up to five consecutive. days. For comparison, a gastric fistula model was used. Effects of ghrelin and esomeprazole, with or without pentagastrin, on gastric pH were studied. In addition, effects of esomeprazole on plasma ghrelin, gastrin and somatostatin were analyzed.

Results: All rats recovered after surgery. The average 24-h pH during free feeding was 2.3 +/- 0.1 (n = 20) with a variation of 18% +/- 6% over 5 d. Ghrelin, 2400 pmol/kg, t.i.d. increased pH from 1.7 +/- 0.1 to 3.1 +/- 0.3 (P < 0.01) as recorded with the Bravo system. After esomeprazole (1 mg/kg, 3 mg/kg and 5 mg/kg) there was a dose-dependent pH increase of maximally 3.4 +/- 0.1, with day-to-day variation over the entire period of 8% +/- 3%. The fistula and pH studies generated similar results. Acid inhibition with esomeprazole increased plasma ghrelin from 10 +/- 2 pmol/L to 65 +/- 26 pmol/L (P < 0.001), and somatostatin from 10 +/- 2 pmol/L to 67 +/- 18 pmol/L (P < 0.001).

Conclusion: pH measurements with the Bravo capsule are reliable, and comparable to those of the gastric fistula model. The Bravo system optimizes accurate intragastric pH monitoring over prolonged periods and allows both short- and long-term evaluation of effects of drugs and hormones.

Place, publisher, year, edition, pages
2008. Vol. 14, no 40, 6180-6187 p.
Keyword [en]
Gastric acid, Bravo system, Intragastric pH, Ghrelin, Somatostatin
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16088DOI: 10.3748/wjg.14.6180OAI: diva2:133131
Available from: 2009-01-07 Created: 2009-01-07 Last updated: 2009-08-20

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Theodorsson, Elvar
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