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Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - A microdialysis study of women
Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
University of Heidelberg.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine . Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
National Research Centre for the Working Environment.
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2008 (English)In: PAIN, ISSN 0304-3959, Vol. 139, no 3, 578-587 p.Article in journal (Refereed) Published
Abstract [en]

The origins of chronic Muscle pain development and maintenance are debated regarding the relative contributions of peripheral nociception and central pain processing. Bradykinin (BKN) and kallidin (KAL) have been suggested to be algesic kinins involved in muscle pain. This in vivo study investigates whether there were significant differences in interstitial muscle concentrations of BKN and KAL between chronic work-related trapezius myalgia (TM), chronic whiplash associated disorders (WAD), and healthy controls (CON). These subjects were studied Lit rest, during a 20-min repetitive low-force exercise and recovery. The interstitial concentrations of BKN and KAL of trapezius were determined using the microdialysis technique. The interstitial concentration of KAL was overall significantly higher in TM than in CON. [KAL] and [BKN] increased significantly during the brief exercise in all groups. The increase in [BKN] during exercise was significantly higher in TM than in the other two groups,whereas the increase in [KAL] during exercise was highest in WAD. In chronic pain, positive correlations existed between the two kinins and the difference in pain intensity between recovery and baseline. In this in vivo study of two groups of patients with chronic pain clinically involving the trapezius muscle, we found alterations - most prominent in TM in the interstitial concentrations of BKN and KAL. The results indicated that the two kinins were involved in aspects of hyperalgesia.

Place, publisher, year, edition, pages
2008. Vol. 139, no 3, 578-587 p.
Keyword [en]
Bradykinin, Human, Kallidin, Microdialysis, Muscle, Pain, Woman
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16096DOI: 10.1016/j.pain.2008.06.012OAI: oai:DiVA.org:liu-16096DiVA: diva2:133146
Available from: 2009-01-07 Created: 2009-01-07 Last updated: 2009-08-18

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Gerdle, BjörnLarsson, Britt

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