High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry
2008 (English)In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 26, no 4, 241-247 p.Article in journal (Refereed) Published
Objectives: To evaluate to what extent emphysema was evident, as identified by High Resolution Computed Tomography (HRCT), in smokers with normal lung function and to relate age, gender, smoking history, and body mass index (BMI) to the HRCT results. A secondary aim was to study to what extent emphysema was present in smokers with lower normal values of lung function defined as FEV1/FVC ratio percentage of predicted value (89-93% of predicted value for males and 90-93% for females) or FEF50 60% of predicted compared with smokers without this definition.
Methods: Fifty-nine smokers, with a mean age of 53 years and with normal lung function, were examined with HRCT.
Results: Emphysema evidenced visually by HRCT was present in 43% of the subjects. Using a 0-5 grade scale (0=normal finding; 5=emphysema in most slices), the degree of emphysema was almost exclusively 3-4. The type of emphysema was distributed as centrilobular emphysema predominant in 43.5%, paraseptal emphysema predominant in 43.5%, and as an equal mixture of these types in 13%. The presence of emphysema did not differ between the group of smokers with lower normal values of lung function and the rest of the smokers. Smokers with emphysema had significantly lower BMI than those devoid of emphysema, 24 and 27 respectively (p0.0011).
Conclusion: There was a high occurrence of visual emphysema in middle-aged smokers with normal lung function. The densitometric quantitative analysis method is inadequate for detecting mild emphysema. High prevalence of emphysema was associated with low BMI.
Place, publisher, year, edition, pages
2008. Vol. 26, no 4, 241-247 p.
Body mass index, computed tomography, family practice, pulmonary emphysema, smoking, spirometry
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16159DOI: 10.1080/02813430802452732OAI: oai:DiVA.org:liu-16159DiVA: diva2:133249