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Optoelectronic control of single cells using organic photocapacitors
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. (Wallenberg Centre for Molecular Medicine)
Med Univ Graz, Austria.
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2019 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 5, no 4, article id eaav5265Article in journal (Refereed) Published
Abstract [en]

Optical control of the electrophysiology of single cells can be a powerful tool for biomedical research and technology. Here, we report organic electrolytic photocapacitors (OEPCs), devices that function as extracellular capacitive electrodes for stimulating cells. OEPCs consist of transparent conductor layers covered with a donor-acceptor bilayer of organic photoconductors. This device produces an open-circuit voltage in a physiological solution of 330 mV upon illumination using light in a tissue transparency window of 630 to 660 nm. We have performed electrophysiological recordings on Xenopus laevis oocytes, finding rapid (time constants, 50 mu s to 5 ms) photoinduced transient changes in the range of 20 to 110 mV. We measure photoinduced opening of potassium channels, conclusively proving that the OEPC effectively depolarizes the cell membrane. Our results demonstrate that the OEPC can be a versatile nongenetic technique for optical manipulation of electrophysiology and currently represents one of the simplest and most stable and efficient optical stimulation solutions.

Place, publisher, year, edition, pages
Washington, DC, United States: American Association for the Advancement of Science (A A A S) , 2019. Vol. 5, no 4, article id eaav5265
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-158380DOI: 10.1126/sciadv.aav5265ISI: 000466398400064PubMedID: 30972364Scopus ID: 2-s2.0-85064722157OAI: oai:DiVA.org:liu-158380DiVA, id: diva2:1333596
Note

Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Foundation for Strategic Research (SSF); Swedish Research Council (Vetenskapsradet) [2018-04505]

Available from: 2019-07-01 Created: 2019-07-01 Last updated: 2019-08-09Bibliographically approved

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