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Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy
Stockholm Univ, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Skandion Clin, Sweden.ORCID iD: 0000-0001-8171-2541
Stockholm Univ, Sweden; Karolinska Inst, Sweden.
2019 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 39, no 5, p. 2337-2340Article in journal (Refereed) Published
Abstract [en]

Background/Aim: This study investigated the impact of temporary vascular collapse on tumour control probability (TCP) in stereotactic body radiotherapy (SBRT), taking into account different radiosensitivities of chronically and acutely hypoxic cells. Materials and Methods: Three-dimensional tumours with heterogeneous oxygenation were simulated assuming different fractions of collapsed vessels at every treatment fraction. The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction amp;lt;= 5 mm Hg of 30-50%. The rest of the tumours were well-oxygenated at the start of the simulated treatment. Results: For all simulated cases, the largest reduction in TCP from 97% to 2% was found in a tumour with a small chronically hypoxic core treated with 60 Gy in eight fractions and assuming a treatment-induced vascular collapse of 35% in the well-oxygenated region. Conclusion: The timing of SBRT fractions should be considered together with the tumour oxygenation to avoid loss of TCP in SBRT.

Place, publisher, year, edition, pages
INT INST ANTICANCER RESEARCH , 2019. Vol. 39, no 5, p. 2337-2340
Keywords [en]
Hypoxia; vascular damage; stereotactic body radiotherapy; SBRT; tumour control probability; TCP; tumour oxygenation
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-158344DOI: 10.21873/anticanres.13350ISI: 000469427800011PubMedID: 31092425OAI: oai:DiVA.org:liu-158344DiVA, id: diva2:1333853
Note

Funding Agencies|Cancer Research Funds of Radiumhemmet (Solna, Sweden)

Available from: 2019-07-02 Created: 2019-07-02 Last updated: 2019-07-02

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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiation Physics
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