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Improved cell mediated immune responses after successful re-vaccination of non-responders to the hepatitis B virus surface antigen (HBsAg) vaccine using the combined hepatitis A and B vaccine
Karolinska University Hospital.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases . Östergötlands Läns Landsting, Centre for Medicine, Department of Infectious Diseases in Östergötland.
Karolinska University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases . Linköping University, Faculty of Health Sciences.
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2008 (English)In: Vaccine, ISSN 0264-410X, Vol. 26, no 47, 5967-5972 p.Article in journal (Refereed) Published
Abstract [en]

We Successfully re-vaccinated hepatitis B Virus (HBV) vaccine non-responders Using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical adjuvant-effect from the local presence of a HAV-specific CMI. A few non-responders had a detectable HBsAg-specific CMI before re-vaccination. An in vitro detectable HBsAg-specific CMI was primed equally effective in non-responders (58%) as in first time vaccine recipients (68%). After the third dose a weak, albeit significant, association was observed between the magnitude of HBsAg-specific proliferation and anti-HBs levels. This regimen improves the priming of HBsAg-specific CMIs and antibodies.

Place, publisher, year, edition, pages
2008. Vol. 26, no 47, 5967-5972 p.
Keyword [en]
Hepatitis B virus, HBV, HBsAg, Vaccine, Non-responder
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16233DOI: 10.1016/j.vaccine.2008.08.054OAI: oai:DiVA.org:liu-16233DiVA: diva2:133487
Available from: 2009-01-12 Created: 2009-01-09 Last updated: 2009-09-21

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Cardell, Kristina

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Faculty of Health SciencesInfectious Diseases Department of Infectious Diseases in Östergötland
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CiteExportLink to record
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  • de-DE
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