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Genomic analysis of Staphylococcus aureus along a pork production chain and in the community, Shandong Province, China
China Agr Univ, Peoples R China.
Shandong Ctr Dis Control and Prevent, Peoples R China.
Publ Hlth Agcy Sweden, Sweden; Karolinska Inst, Sweden.
China Agr Univ, Peoples R China; Free Univ Berlin, Germany.
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2019 (English)In: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 54, no 1Article in journal (Refereed) Published
Abstract [en]

Livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) is an increasingly important public health concern worldwide; however, data on LA-MRSA from Asian countries is scarce. As such, a comprehensive molecular epidemiological survey of S. aureus along a pork production chain and in the community was undertaken in Shandong Province, China. spa typing and whole-genome sequencing were used to survey the occurrence and potential transmission of S. aureus in various sectors, including 899 porcine samples (snout or skin swabs, carcass swabs and pork portions), 845 human nasal samples and 239 environmental samples from commercial farms, a slaughterhouse, a pork wholesale market and the surrounding community. MRSA was detected in higher frequencies in samples from two commercial pig farms (pigs, 49%; farm workers, 64%; environmental samples, 16%) than in samples from the slaughterhouse (fatteners, 8.2%; carcasses, 1.1%; operation workers, 0%; environmental samples, 3.8%), the pork wholesale market (pork, 14%; sellers, 0%) and individuals in the community (6.8%). There were significant differences in population structures, antimicrobial susceptibility profiles, and the presence of resistance and virulence genes between human- and pig-associated isolates. The phylogenetic analysis confirmed the dissemination of LA-MRSA between various segments along the pork production chain. However, MRSA of the same sequence type was not found to be disseminated between the commercial farms and the surrounding communities. Furthermore, one MRSA ST398 was observed, and a novel CC9 variant ST3597 was detected within the chain. The high MRSA carriage rates and the emergence of a new MRSA CC9 variant identified in this study highlight the need for MRSA surveillance. (C) 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 54, no 1
Keywords [en]
LA-MRSA; China; Pork production chain; Community; Whole-genome sequencing
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-158536DOI: 10.1016/j.ijantimicag.2019.03.022ISI: 000470969800002PubMedID: 30959181OAI: oai:DiVA.org:liu-158536DiVA, id: diva2:1334928
Note

Funding Agencies|National Natural Science Foundation of China [31472237, 31761133022, 81361138021, 31422055]; Swedish Research Council (Sino-Swedish IMPACT project) [D0879801]; German Research Foundation [SCHW382/11-1]; Shandong Provincial Natural Science Foundation [BS2014SW020]; China Postdoctoral Science Foundation [2018M640206]

Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-07-03

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Nilsson, Lennart EBörjesson, Stefan
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