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Management and outcome of TaG3 tumours of the urinary bladder in the nationwide, population-based bladder cancer database Sweden (BladderBaSe)
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
Karolinska Inst, Sweden.
Karolinska Univ Hosp, Sweden.
Orebro Univ Hosp, Sweden.
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(English)In: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813Article in journal (Refereed) Epub ahead of print
Abstract [en]

Purpose: To investigate the management of TaG3 tumours of the urinary bladder using nationwide population-based data in relation to the prevailing guidelines, patients characteristics, and outcome. Materials and methods: The Bladder Cancer Data Base Sweden (BladderBaSe), including data from the Swedish National Register for Urinary Bladder Cancer (SNRUBC), was used to study all patients with TaG3 bladder cancer diagnosed from 2008 to 2014. Patients were divided into the following management groups: (1) transurethral resection (TUR) only, (2) TUR and intravesical instillation therapy (IVIT), (3) TUR and second-look resection (SLR), and (4) TUR with both SLR and IVIT. Patient and tumour characteristics and outcome were studied. Results: There were 831 patients (83% males) with a median age of 74 years. SLR was performed more often on younger patients, on men, and less often in the Western and Uppsala/orebro Healthcare regions. IVIT was performed more often with younger patients, with men, in the Western Healthcare region, and less often in the Uppsala/orebro Healthcare region. Death from bladder cancer occurred in 6% of cases within a median of 29 months (0-84 months) and was lower in the TUR/IVIT and TUR/SLR/IVIT groups compared to the other two groups. Conclusion: In the present study, there was, according to the prevailing treatment guidelines, an under-treatment with SLR for older patients, women, and in some healthcare regions and, similarly, there was an under-treatment with IVIT for older patients. Cancer-specific survival and relative survival were lower in the TUR only group compared to the TUR/IVIT and TUR/SLR/IVIT groups.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD.
Keywords [en]
Bladder cancer; population-based; TaG3; second-look resection; intravesical instillation treatment
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:liu:diva-158816DOI: 10.1080/21681805.2019.1621377ISI: 000471561600001PubMedID: 31144582OAI: oai:DiVA.org:liu-158816DiVA, id: diva2:1337523
Note

Funding Agencies|Swedish Cancer Society [CAN 2016/470, CAN 278]

Available from: 2019-07-15 Created: 2019-07-15 Last updated: 2019-07-15

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Jahnson, StaffanRosell, JohanAljabery, Firas
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Urology in ÖstergötlandDivision of Clinical SciencesRegional Cancer Center South East SwedenDepartment of Clinical and Experimental Medicine
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Scandinavian journal of urology
Urology and Nephrology

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