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Ratiometric fluorogenic determination of endogenous hypochlorous acid in living cells
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering. Shanghai Univ, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Tongji Univ, Peoples R China.
Tongji Univ, Peoples R China.
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2019 (English)In: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, E-ISSN 1873-3557, Vol. 219, p. 232-239Article in journal (Refereed) Published
Abstract [en]

Hypochlorous acid (HClO) is one of the most important ROS (reactive oxygen species) and common pollutant in tap-water. However, the determination of HClO with fast response and high sensitivity/selectivity is still an urgent demanding. Here we fabricated a ratiometric fluorescent probe RC based on TBET (through-bond energy transfer) on the platform of coumarin and rhodamine with the thiosemicarbazide group as the linker. This probe could display the characteristic fluorescence emission of coumarin. Upon addition of HClO, the linker was reacted into an oxadiazole, resulting in the opening of spiro-ring of rhodamine. The resultant then gives ratiometric fluorogenic changes. The probe exhibits fast response and high selectivity and sensitivity towards HClO with a low limit of detection (similar to 140 nM). Eventually, RC is successfully applicated for determining spiked HClO in water samples and imaging endogenous HClO in living cells. (C) 2019 Published by Elsevier B.V.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 219, p. 232-239
Keywords [en]
Coumarin; Rhodamine; Hypochlorous acid; Ratiometric; Fluorescence
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Identifiers
URN: urn:nbn:se:liu:diva-158808DOI: 10.1016/j.saa.2019.04.024ISI: 000472094000029PubMedID: 31048252OAI: oai:DiVA.org:liu-158808DiVA, id: diva2:1337792
Note

Funding Agencies|Natural Science Foundation of Shanghai [17ZR1410500]; National Natural Science Foundation of China [21577098, 21477073]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]

Available from: 2019-07-17 Created: 2019-07-17 Last updated: 2019-07-17

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