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Factors associated with health-related quality of life among adults with tetralogy of Fallot
Umea Univ, Sweden.
Umea Univ, Sweden.
Umea Univ, Sweden.
Umea Univ, Sweden.
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2019 (English)In: Open heart, E-ISSN 2053-3624, Vol. 6, no 1, article id UNSP e000932Article in journal (Refereed) Published
Abstract [en]

Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ5D index was calculated and dichotomised into best possible health-related QoL (EQ-5D index = 1) or differed from 1. Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity amp;gt; 3 h/ week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D index was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 to 16.12) and physical activity amp;gt; 3 h/ week (OR 2.27, 95% CI 1.07 to 4.84) remained associated with best possible health-related QoL. Replacing NYHA with symptoms in the model yielded similar results. Conclusion In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2019. Vol. 6, no 1, article id UNSP e000932
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-159020DOI: 10.1136/openhrt-2018-000932ISI: 000471922200023PubMedID: 30997127OAI: oai:DiVA.org:liu-159020DiVA, id: diva2:1338067
Note

Funding Agencies|Vasterbotten Lans Landsting, Norrlandska Hjartfonden; Hjart-Lungfonden

Available from: 2019-07-19 Created: 2019-07-19 Last updated: 2019-11-14

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Nielsen, Niels Erik
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
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