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Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats
Univ Belgrade, Serbia.
Univ Belgrade, Serbia.
Germans Trias and Pujol Univ Hosp and Res Inst, Spain; Univ Autonoma Barcelona, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Univ Belgrade, Serbia.
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2019 (English)In: Immunobiology, ISSN 0171-2985, E-ISSN 1878-3279, Vol. 224, no 3, p. 470-476Article in journal (Refereed) Published
Abstract [en]

Dendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Tolerogenic DC (tolDC) obtained by vitamin D3 treatment were studied in parallel. Profile of cytokine production was different in AO and DA mDC and tolDC. Expression of MHC class II molecules and CD86 were higher in DA DC, while vitamin D3 reduced their expression in dendritic cells of both strains. Allogeneic proliferation of CD4(+) T cells was reduced by AO tolDC, but not with DA tolDC in comparison to respective mDC. Finally, expression of various genes identified as differentially expressed in human mDC and tolDC was also analyzed in AO and DA DC. Again, AO and DA DC differed in the expression of the analyzed genes. To conclude, AO and DA DC differ in production of cytokines, expression of antigen presentation-related molecules and in regulation of CD4(+) T proliferation. The difference is valuable for understanding the divergence of the strains in their susceptibility to autoimmunity.

Place, publisher, year, edition, pages
ELSEVIER GMBH , 2019. Vol. 224, no 3, p. 470-476
Keywords [en]
Dendritic cells; Autoimmunity; Dark agouti rats; Albino Oxford rats; Allogeneic proliferation
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-158996DOI: 10.1016/j.imbio.2019.01.001ISI: 000473836000019PubMedID: 30765133OAI: oai:DiVA.org:liu-158996DiVA, id: diva2:1338112
Note

Funding Agencies|Ministry of Education, Science and Technological Development of the Republic of Serbia [173035, 173013]; Plan Nacional de I + D + I [PI14/01175, PI17/01521]; ISCIII-Subdireccion General de Evaluaci6n; Fondo Europeo de Desarrollo Regional (FEDER); Short Term Scientific Missions through A FACTT network (Cost Action) [BM1305]; EU Framework Programme Horizon 2020

Available from: 2019-07-19 Created: 2019-07-19 Last updated: 2019-07-19

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