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Work Loss Before and After Diagnosis of Crohns Disease
Karolinska Inst, Sweden.
Karolinska Inst, Sweden; Harvard Med Sch, MA 02115 USA.
Karolinska Inst, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.ORCID iD: 0000-0001-7518-9213
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2019 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 25, no 7, p. 1237-1247Article in journal (Refereed) Published
Abstract [en]

Background The aim of this study was to examine work loss in patients with Crohns disease. Methods Using nationwide registers, we identified incident patients with Crohns disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohns disease or end of follow-up (September 30, 2015). Results Among the 2015 incident Crohns disease patients (median age, 35 years; 50% women), both the proportion with work loss and the mean annual number of lost workdays were larger 5 years before diagnosis (25%; mean, 45 days) than in the 10,067 comparators (17%; mean, 29 days). Increased work loss was seen during the year of diagnosis, after which it declined to levels similar to before diagnosis. Of all patients, 75% had no work loss 24-12 months before diagnosis. Of them, 84% had full work ability also 12-24 months after diagnosis. In patients with total work loss (8.3% of all) before diagnosis, 83% did not work after. Among those with full work ability before diagnosis, the absolute risk of having total work loss after diagnosis was 1.4% (0.43% in the comparators). Our results were consistent across several sensitivity analyses using alternative definitions for date of diagnosis. Conclusions Patients with Crohns disease had increased work loss several years before diagnosis, possibly explained by comorbidity or by diagnostic delay.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2019. Vol. 25, no 7, p. 1237-1247
Keywords [en]
sick leave; disability pension; Crohns disease; IBD; diagnostic delay; comorbidity
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-158935DOI: 10.1093/ibd/izy382ISI: 000473764400022PubMedID: 30551185OAI: oai:DiVA.org:liu-158935DiVA, id: diva2:1338194
Note

Funding Agencies|Karolinska Institutet (KI SOS); Swedish Research Council; Swedish Cancer Society; Heart Lung Foundation; Swedish Medical Society; Swedish Medical Society (Fund for Research in Gastroenterology); Swedish Medical Society (Ihre Foundation); Stiftelsen Tornspiran; Mag-tarmfonden; Jane and Dan Olsson Foundation; Mjolkdroppen Foundation; Bengt Ihre Research Fellowship in Gastroenterology; Karolinska Institutet; Stockholm County Council

Available from: 2019-07-20 Created: 2019-07-20 Last updated: 2019-07-20

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Myrelid, Pär
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Surgery in Linköping
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