liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
DanTrials AS, Denmark.
Show others and affiliations
2008 (English)In: Pain, ISSN 0304-3959, Vol. 140, no 3, 479-490 p.Article in journal (Refereed) Published
Abstract [en]

The trapezius muscle often develops pain as the result of repetitive and stressful work tasks although it is unclear to what extent this pain is due to alterations in muscle concentrations of algesic/nociceptive substances. Twenty women with chronic neck- and shoulder pain (TM) whose work required highly repetitive work tasks and 20 pain-free female colleagues (CON) were studied during and after a full 8-hour workday. We collected microdialysates from their dominant/most painful trapezius muscle; concentrations of serotonin, glutamate, lactate, pyruvate, potassium, bradykinin, and cytokines and blood flow were determined. In addition, we measured surface electromyogram, task exposure level, pain intensity, perceived mental stress, and urine-cortisol. In connection to the clinical neck and Shoulder examination, we determined pressure pain thresholds (PPTs) over the trapezius and tibialis muscles. TM had higher concentrations Of glutamate (71 +/- 42 vs. 36 +/- 15 mu mol l(-1)) and pyruvate (187 +/- 89 vs. 125 +/- 63 mu mol l(-1)) than CON. Interstitial serotonin was higher ill TM (before work: 10.6 +/- 10.8 vs. 2.2 +/- 1.2 nM; after work: 9.2 +/- 8.3 vs. 1.5 +/- 2.9 nM). The trapezius blood flow during the working day was higher in TM than in CON. TM had lower PPT and higher pain intensity throughout the working day. No differences in EMG, task exposure level, Mental Stress, Or Urine-cortisol in the groups were found. These findings Support the idea that peripheral nociceptive processes are activated ill Occupationally active Subjects, who are diagnosed with trapezius myalgia. In contrast, no sign of low blood flow or increased stress or muscle activity markers were found in TM.

Place, publisher, year, edition, pages
2008. Vol. 140, no 3, 479-490 p.
Keyword [en]
Blood flow, Pyruvate, Serotonin, Glutamate, Muscle pain, Nociception, Work
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16346DOI: 10.1016/j.pain.2008.10.001OAI: diva2:133963
Available from: 2009-01-16 Created: 2009-01-16 Last updated: 2009-08-19

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Larsson, BrittGhafouri, BijarAbdiu, AvniGerdle, Björn
By organisation
Department of Clinical and Experimental MedicineFaculty of Health SciencesPain and Rehabilitation CentreDepartment of Plastic Surgery, Hand surgery UHL
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 100 hits
ReferencesLink to record
Permanent link

Direct link