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Dissemination of extended-spectrum beta-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health
Shandong Univ, Peoples R China.
Zhejiang Univ, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences. Zhejiang Univ, Peoples R China.
Shandong Univ, Peoples R China.
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2019 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 251, p. 619-627Article in journal (Refereed) Published
Abstract [en]

Antibiotic resistance among gram-negative bacteria is increasingly becoming a problem of global concern. Particularly problematic is the emergence of resistance to last-resort antibiotics such as carbapenems and colistin. The increasing number of reports on the plasmid-mediated colistin resistance gene mcr-1 in isolates worldwide is raising concerns for the future usefulness of this class of antibiotics. Dissemination of mcr-1 is believed to have originated mainly from animal breeding, however, the role of the environment as a transmission source is not yet fully understood. In the current study, 89 extended spectrum beta-lactamase-producing Escherichia coli isolated from 231 samples from different environmental sources in 12 villages in a rural area of Shandong, China, were screened for mcr-1.17 (19.1%) mcr-1-positive isolates were found from different environmental sources, aggregated in 6 villages. Plasmids of three different Inc-groups carrying mcr-1 were confirmed, indicating that the widespread geographical distribution of mcr-1 in the local area is due to a number of different plasmids. Additionally, almost a third (29.4%) of the isolates carried virulence factors associated to intestinal pathogenic E. coli. These results illustrate the high complexity of the transmission patterns of mcr-1 among different environmental matrices on a local scale and the potential for the environment to facilitate dissemination and emergence of antibiotic-resistant and virulent strains of bacteria. (C) 2019 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 251, p. 619-627
Keywords [en]
Escherichia coli; mcr-1; Environment; Virulence factors; Whole-genome sequencing
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:liu:diva-159135DOI: 10.1016/j.envpol.2019.05.002ISI: 000474329700068PubMedID: 31108295OAI: oai:DiVA.org:liu-159135DiVA, id: diva2:1339668
Note

Funding Agencies|National Natural Science Foundation of China [41771499, 81361138021]; Fundamental Research Funds of Shandong University [2018JC102]; Swedish Research Council; Public Health Agency of Sweden [D0879801]; Swedish Research Council Formas [2016-00640]

Available from: 2019-07-30 Created: 2019-07-30 Last updated: 2019-07-30

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