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Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant
Linköping University, Department of health and environment. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
2009 (English)In: International journal of legal medicine (Print), ISSN 0937-9827, Vol. 123, no 1, 47-53 p.Article in journal (Refereed) Published
Abstract [en]

A case of sudden infant death with histiocytoid cardiomyopathy and ventricular non-compaction was investigated with immunohistochemical methods. Histiocytoid cardiomyopathy is thought to be a developmental defect of the cardiomyocytes of the conduction system. In contrast to mature cardiomyocytes, the histiocytoid cells showed only weak reactions to desmin and myosin antibodies. They lacked cross-striation but reacted strongly to enolase and myoglobin antibodies. The protein Pax-7, seen only in cells undergoing differentiation, and the proliferation marker Ki-67 were not expressed in the histiocytoid cells. In areas of altered myocardium, clusters of CD4-, CD8-, and CD68-positive inflammatory cells were seen as well an abundance of mast cells. With the TUNEL method, it was found that many of the histiocytoid cells were undergoing apoptosis. Our results confirm that the histiocytoid cells are defective cardiomyocytes. The apoptotic and inflammatory changes point to a degenerative process rather than defective maturation of cardiomyocytes as has been suggested in some earlier studies. Ventricular non-compaction is a developmental defect of the subendocardial tissue with hypertrabeculation and weak development of the papillary muscles. Only one case combined with histiocytoid cardiomyopathy has been described previously. A causal connection between the two conditions cannot be established until more cases have been analyzed.

Place, publisher, year, edition, pages
2009. Vol. 123, no 1, 47-53 p.
Keyword [en]
Histiocytoid cardiomyopathy, Ventricular non-compaction, Sudden death, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16350DOI: 10.1007/s00414-008-0236-4OAI: diva2:133967
Available from: 2009-01-16 Created: 2009-01-16 Last updated: 2009-04-26

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Edston, ErikPerskvist , Nasrin
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Department of health and environmentFaculty of Health SciencesDepartment of Clinical and Experimental Medicine
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