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Precisely Defined Conjugated Oligoelectrolytes for Biosensing and Therapeutics
Univ Calif Santa Barbara, CA 93106 USA.
Univ Calif Santa Barbara, CA 93106 USA.
Chinese Acad Sci, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
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2019 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 31, no 22, article id 1806701Article, review/survey (Refereed) Published
Abstract [en]

Conjugated oligoelectrolytes (COEs) are a relatively new class of synthetic organic molecules with, as of yet, untapped potential for use in organic optoelectronic devices and bioelectronic systems. COEs also offer a novel molecular approach to biosensing, bioimaging, and disease therapy. Substantial progress has been made in the past decade at the intersection of chemistry, materials science, and the biological sciences developing COEs and their polymer analogues, namely, conjugated polyelectrolytes (CPEs), into synthetic systems with biological and biomedical utility. CPEs have traditionally attracted more attention in arenas of sensing, imaging, and therapy. However, the precisely defined molecular structures and interactions of COEs offer potential key advantages over CPEs, including higher reliability and fluorescence quantum efficiency, larger diversity of subcellular targeting strategies, and improved selectivity to biomolecules. Here, the unique-and sometimes overlooked-properties of COEs are discussed and the noticeable progress in their use for biological sensing, imaging, and therapy is reviewed.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2019. Vol. 31, no 22, article id 1806701
Keywords [en]
antibacterials; biological imaging; biological sensing; cancer therapy; conjugated oligoelectrolytes
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-159291DOI: 10.1002/adma.201806701ISI: 000475696300005PubMedID: 30698856OAI: oai:DiVA.org:liu-159291DiVA, id: diva2:1341114
Note

Funding Agencies|Institute for Collaborative Biotechnologies [W911NF-09-D-0001]; U.S. Army Research Office

Available from: 2019-08-07 Created: 2019-08-07 Last updated: 2019-08-07

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