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Anterior CNS expansion driven by brain transcription factors
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Univ Cambridge, England.ORCID iD: 0000-0002-5712-3031
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Inst, Sweden.ORCID iD: 0000-0002-4221-6243
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences. Univ Queensland, Australia.ORCID iD: 0000-0001-5095-541X
2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e45274Article in journal (Refereed) Published
Abstract [en]

During CNS development, there is prominent expansion of the anterior region, the brain. In Drosophila, anterior CNS expansion emerges from three rostral features: (1) increased progenitor cell generation, (2) extended progenitor cell proliferation, (3) more proliferative daughters. We find that tailless (mouse Nr2E1/Tlx), otp/Rx/hbn (Otp/Arx/Rax) and Doc1/2/3 (Tbx2/3/6) are important for brain progenitor generation. These genes, and earmuff (FezF1/2), are also important for subsequent progenitor and/or daughter cell proliferation in the brain. Brain TF comisexpression can drive brain-profile proliferation in the nerve cord, and can reprogram developing wing discs into brain neural progenitors. Brain TF expression is promoted by the PRC2 complex, acting to keep the brain free of anti-proliferative and repressive action of Hox homeotic genes. Hence, anterior expansion of the Drosophila CNS is mediated by brain TF driven super-generation of progenitors, as well as hyper-proliferation of progenitor and daughter cells, promoted by PRC2-mediated repression of Hox activity.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e45274
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-159263DOI: 10.7554/eLife.45274ISI: 000475749800001PubMedID: 31271353OAI: oai:DiVA.org:liu-159263DiVA, id: diva2:1341157
Note

Funding Agencies|Knut och Alice Wallenbergs Stiftelse [KAW2011.0165, KAW2012.0101]; Vetenskapsradet [621-2013-5258]; Cancerfonden [140780, 150663]

Available from: 2019-08-07 Created: 2019-08-07 Last updated: 2019-08-07

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Rodriguez Curt, JesúsYaghmaeian Salmani, BehzadThor, Stefan
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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