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Gene expression across mammalian organ development
Heidelberg Univ ZMBH, Germany; Univ Lausanne, Switzerland.
Univ Lausanne, Switzerland.
Univ Lausanne, Switzerland.
European Mol Biol Lab, Germany.
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2019 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 571, no 7766, p. 505-+Article in journal (Refereed) Published
Abstract [en]

The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 571, no 7766, p. 505-+
National Category
Genetics
Identifiers
URN: urn:nbn:se:liu:diva-159572DOI: 10.1038/s41586-019-1338-5ISI: 000477016700059PubMedID: 31243369OAI: oai:DiVA.org:liu-159572DiVA, id: diva2:1342418
Note

Funding Agencies|Maryland Brain Collection Center [MR/R006237/1]; state of Baden-Wurttemberg through bwHPC; German Research Foundation; National Institutes of Health; European Research Council [SFB 1036]; National Natural Science Foundation of China [322206]; Fundacao para a Ciencia e Tecnologia through POPH-QREN [31771410, 91731302]; European Social Fund; Portuguese MCTES [IF/00283/2014/CP1256/CT0012]; Swiss National Science Foundation [615253]; [146474]; [329902]

Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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