Tobacco smoking and alcohol consumption as risk factors for thymoma - A European case-control studyShow others and affiliations
2019 (English)In: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 61, p. 133-138Article in journal (Refereed) Published
Abstract [en]
Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35-69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set of controls, used in seven parallel case-control studies by the same research group was used, including population-based controls from five countries and hospital controls with colon cancer from two countries. Altogether 103 cases, accepted by a reference pathologist, 712 colon cancer controls, and 2071 population controls were interviewed. Results: Tobacco smoking was moderately related with thymoma (OR 1.4, 95% CI 0.9-2.2), and a tendency to dose-response was shown (p = 0.04), with an increased risk for heavy smokers defined as amp;gt;= 41 pack-years (OR 2.1, 95% CI 1.1-3.9). A high consumption of spirits defined as amp;gt;= 25 g of alcohol per day was associated with an increased risk of thymoma (OR 2.4, 95% CI 1.1-5.4), whereas no association was found with beer or wine. Conclusions: Tobacco smoking and a high intake of spirits were indicated as risk factors for thymoma.
Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 61, p. 133-138
Keywords [en]
Thymoma; Thymus cancer; Tobacco smoking; Alcohol; Risk factors; Case-control study
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-159565DOI: 10.1016/j.canep.2019.06.008ISI: 000476631100018PubMedID: 31254794OAI: oai:DiVA.org:liu-159565DiVA, id: diva2:1342465
Note
Funding Agencies|European Commission [BMH1 CT 93-1630]; Denmark: The strategic Environment Programme [92.01.015.7-06]; Denmark: Danish Epidemiology Science Centre - Danish National Research Foundation; France: Ligue Nationale contre le cancer; France: Federation Nationale des Centres de Lutte contre le Cancer; France: Fondation de France [955368]; France: Institut National de la Sante et de la Recherche Medicale (INSERM) [4R006A]; France: French Ministry of Environment [237.01.94.40182]; Germany: Federal Ministry for Education, Science, Research and Technology (BMBF) [01-HP-684/8]; Italy: The Italian Association for Cancer Research (AIRC), Special Project Oncology, Compagnia di San Paolo/FIRMS, MURST, Region Piedmont; Spain: Fondo de Investigacion de la Sanitarie; Spain: Departmento de Sanidad y Consumo, Gobierno Vasco; Spain: Fondo de Investigacion de la Sanitaria, Ministerio de Sanidad y Consumo, Ayuda a la Investigacion del Departamento de Salud del Gobierno de Navarra; Sweden: Swedish Council for Work Life Research; Sweden: Research Foundation of the Department of Oncology in Umea; Sweden: Swedish Society of Medicine; Sweden: Lund University Hospital Research Foundation; Sweden: Gunnar, Arvid and Elisabeth Nilsson Cancer Foundation; Sweden: Orebro County Council Research Committee; Sweden: Orebro Medical Center Research Foundation; Sweden: John and Augusta Persson Foundation for Scientific Medical Research; Sweden: Berta Kamprad Foundation for Cancer Research; Spain: Ministerio de Sanidad y Consumo; Spain: Unidad de Investigacion Clinico-Epidemiologica; Spain: Hospital Dr. Peset. Generalitat Valenciana [FISS. 95/0044-01, 96/0043-01]
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