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A Population-Based Comparison of the AJCC 7th and AJCC 8th Editions for Patients Diagnosed with Stage III Cutaneous Malignant Melanoma in Sweden
Lund Univ, Sweden.
Univ Gothenburg, Sweden.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Business support and Development, Regional Cancer Center.
Lund Univ, Sweden.
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2019 (English)In: Annals of Surgical Oncology, ISSN 1068-9265, E-ISSN 1534-4681, Vol. 26, no 9, p. 2839-2845Article in journal (Refereed) Published
Abstract [en]

Background

Cutaneous melanoma is steadily increasing worldwide. The new AJCC 8th edition was recently launched and introduced several changes in melanoma staging, particularly for stage III. We conducted a population-based registry study with the purpose to evaluate the impact and prognostic accuracy of the new classification in Sweden.

Methods

Consecutive patients diagnosed with stage III melanoma between January 2005 and September 2017 were identified by the Swedish Melanoma Registry (SMR) and included for analyses. Patients with multiple primary melanomas were excluded. Patients were classified according to the AJCC 7th as well as the 8th edition. Melanoma-specific survival (MSS) was retrieved from the Swedish Cause of Death Registry.

Results

A total of 2067 eligible patients were identified from the SMR; 1150 patients (57%) changed stage III subgroup when reclassified according to the AJCC 8th edition. The median 5- and 10-year MSS for the whole cohort of stage III melanoma patients was 59% and 51% respectively. The MSS for substage IIIA, B, and C were all improved when patients were reclassified by using to the AJCC 8th edition. The newly defined substage IIID had the worst prognosis with a 10-year MSS of 16%.

Conclusions

A high proportion of patients diagnosed with stage III melanoma in Sweden between 2005 and 2017 was restaged to another subgroup, when they were reclassified according to the AJCC 8th of staging manual. We established an improved MSS for all substages compared with the former AJCC 7th edition. This may have implications on decisions about adjuvant treatment.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2019. Vol. 26, no 9, p. 2839-2845
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-159703DOI: 10.1245/s10434-019-07448-yISI: 000478894200028PubMedID: 31111349Scopus ID: 2-s2.0-85066134669OAI: oai:DiVA.org:liu-159703DiVA, id: diva2:1343911
Note

Funding Agencies|S. Paulsson Fund; M. Paulsson Fund; Knut and Alice Wallenberg Foundation (WCMTM); Swedish government (ALF) [76670, 826061]; county councils (ALF) [76670, 826061]; Kamprad Foundation; Craaford Foundation; Gunnar Nilsson Foundation; Region Skane; Lund University

Available from: 2019-08-19 Created: 2019-08-19 Last updated: 2019-08-26Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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