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Prospective study of growth and bone mass in Swedish children treated with the modified Atkins diet
Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Chemistry. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
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2019 (English)In: European journal of paediatric neurology, ISSN 1090-3798, E-ISSN 1532-2130, Vol. 23, no 4, p. 629-638Article in journal (Refereed) Published
Abstract [en]

Purpose: The modified Atkins diet (MAD) is a less restrictive treatment option than the ketogenic diet (KD) for intractable epilepsy and some metabolic conditions. Prolonged KD treatment may decrease bone mineralization and affect linear growth; however, long-term studies of MAD treatment are lacking. This study was designed to assess growth, body composition, and bone mass in children on MAD treatment for 24 months. Methods: Thirty-eight patients, mean age (SD) 6.1 years (4.8 years), 21 girls, with intractable epilepsy (n = 22), glucose transporter type 1 deficiency syndrome (n = 7), or pyruvate dehydrogenase complex deficiency (n = 9) were included. Body weight, height, body mass index (BMI), bone mass, and laboratory tests (calcium, phosphorus, magnesium, alkaline phosphatase, cholesterol, 25-hydroxyvitamin D, insulin-like growth factor-I and insulin-like growth factor binding protein 3) were assessed at baseline and after 24 months of MAD treatment. Results: Approximately 50% of the patients responded with more than 50% seizure reduction. Weight and height standard deviation score (SDS) were stable over 24 months, whereas median (minimum maximum) BMI SDS increased from 0.2 (-3.3 to 4.5) to 0.7 (-0.9 to 2.6), p amp;lt; 0.005. No effects were observed for bone mass (total body, lumbar spine and hip) or fat mass. Conclusions: The MAD was efficient in reducing seizures, and no negative effect was observed on longitudinal growth or bone mass after MAD treatment for 24 months. (C) 2019 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 23, no 4, p. 629-638
Keywords [en]
Pediatric; Epilepsy; Vitamin D; Skeleton; Height
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Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-159896DOI: 10.1016/j.ejpn.2019.04.001ISI: 000479022900013PubMedID: 31085021OAI: oai:DiVA.org:liu-159896DiVA, id: diva2:1346135
Note

Funding Agencies|Queen Silvia Childrens Hospital Research Foundation; Torbjorn Jebner foundation; Fetter Silfverskiold foundation; Swedish govemment [ALFGBG-716831, 678871]; Goteborg Medical Society; Region ostergotland; Margaretahemmet foundation; county councils, the ALF [ALFGBG-716831, 678871]

Available from: 2019-08-27 Created: 2019-08-27 Last updated: 2019-08-27

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