liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
High prevalence of pituitary hormone deficiency in both unilateral and bilateral optic nerve hypoplasia
Karolinska Inst, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden.
Karolinska Inst, Sweden; St Erik Eye Hosp, Sweden; Univ Gothenburg, Sweden.
Karolinska Inst, Sweden.
Show others and affiliations
2019 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 108, no 9, p. 1677-1685Article in journal (Refereed) Published
Abstract [en]

Aim This study examined the prevalence of neurological impairment and pituitary hormone deficiency (PHD) in patients with unilateral and bilateral optic nerve hypoplasia (ONH). Methods A population-based cross-sectional cohort study of 65 patients (51% female) with ONH was conducted in Stockholm. Of these were 35 bilateral and 30 unilateral. The patients were below 20 years of age, living in Stockholm in December 2009 and found through database searching. The median age at the analysis of the results in January 2018 was 16.1 years (range 8.1-27.5 years). Neurological assessments and blood sampling were conducted, neuroradiology was reviewed and growth curves were analysed. Diagnoses of PHDs were based on clinical and biochemical evidence of hormone deficiency. Results Neurological impairments were identified in 47% of the patients and impairments in gross and fine motor function were more prevalent in bilateral ONH (p amp;lt; 0.001). In addition, 9% had cerebral palsy and 14% had epilepsy. The prevalence of PHD was 29 and 19% had multiple PHD. Conclusion Children with ONH had a high risk of neurological impairment, especially in bilateral disease. Both unilateral and bilateral ONH signified an increased prevalence of PHD and all these children should be endocrinologically followed up until completed puberty.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 108, no 9, p. 1677-1685
Keywords [en]
Hypopituitarism; Neurological impairment; Optic nerve hypoplasia; Pituitary hormone deficiency; Septo-optic dysplasia
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-159852DOI: 10.1111/apa.14751ISI: 000479320100019PubMedID: 30740788OAI: oai:DiVA.org:liu-159852DiVA, id: diva2:1346295
Note

Funding Agencies|Signhild Engkvist Foundation; Sigvard och Marianne Bernadotte Foundation; Sunnerdahls Handicap Foundation; Frimurare barnhuset Foundation; Linnea och Josef Carlsson Foundation; Ogonfonden; Sallskapet Barnavard; Samariten Foundation

Available from: 2019-08-27 Created: 2019-08-27 Last updated: 2019-08-27

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kristoffersen Wiberg, Maria
By organisation
Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in Linköping
In the same journal
Acta Paediatrica
Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf