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MicroRNAs in the cornea: Role and implications for treatment of corneal neovascularization
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping. Sorlandet Hosp Arendal, Norway.ORCID iD: 0000-0003-1079-4361
2019 (English)In: OCULAR SURFACE, ISSN 1542-0124, Vol. 17, no 3, p. 400-411Article, review/survey (Refereed) Published
Abstract [en]

With no safe and efficient approved therapy available for treating corneal neovascularization, the search for alternative and effective treatments is of great importance. Since the discovery of miRNAs as key regulators of gene expression, knowledge of their function in the eye has expanded continuously, facilitated by high throughput genomic tools such as microarrays and RNA sequencing. Recently, reports have emerged implicating miRNAs in pathological and developmental angiogenesis. This has led to the idea of targeting these regulatory molecules as a therapeutic approach for treating corneal neovascularization. With the growing volume of data generated from high throughput tools applied to study corneal neovascularization, we provide here a focused review of the known miRNAs related to corneal neovascularization, while presenting new experimental data and insights for future research and therapy development.

Place, publisher, year, edition, pages
ELSEVIER , 2019. Vol. 17, no 3, p. 400-411
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:liu:diva-160172DOI: 10.1016/j.jtos.2019.04.002ISI: 000482115800007PubMedID: 30959113OAI: oai:DiVA.org:liu-160172DiVA, id: diva2:1349570
Note

Funding Agencies|Swedish Research Council [2012-2472]; foundation Beth and David Dahlin; KMA Foundation; Crown Princess Margaretas Foundation for the Visually Impaired; charity Synskadades Val

Available from: 2019-09-09 Created: 2019-09-09 Last updated: 2019-09-09

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Mukwaya, AnthonnyJensen, LassePeebo, BeatriceLagali, Neil
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Clinical PharmacologyDepartment of Ophthalmology in Linköping
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