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High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer
Sichuan Univ, Peoples R China.
Sichuan Univ, Peoples R China.
Sichuan Univ, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China.
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2019 (English)In: Future Oncology, ISSN 1479-6694, E-ISSN 1744-8301, Vol. 15, no 18, p. 2093-2106Article in journal (Refereed) Published
Abstract [en]

Aim: To investigate the association and prognostic value of ANKZF1 gene for survival in colorectal cancer, the mechanism of ANKZF1 level alteration and correlated signaling pathways ANKZF1 is involved. Patients amp; methods: The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. Results: High ANKZF1 expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p=0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p=0.042) in colon cancer. Bioinformatical analysis showed ANKZF1 was upregulated by amplification and exon expression. ANKZF1 was associated with angiogenesis and cancer signaling pathways. Conclusion: High ANKZF1 is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.

Place, publisher, year, edition, pages
FUTURE MEDICINE LTD , 2019. Vol. 15, no 18, p. 2093-2106
Keywords [en]
ANKZF1; colon cancer; OS; overall survival; recurrence-free survival; RFS; WGCNA
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-160630DOI: 10.2217/fon-2018-0920ISI: 000485097700004PubMedID: 31257922OAI: oai:DiVA.org:liu-160630DiVA, id: diva2:1360198
Note

Funding Agencies|Natural Science Foundation of ChinaNational Natural Science Foundation of China [81402446]; Research Foundation of Health and Family Planning Commission of Sichuan Province [150136]

Available from: 2019-10-11 Created: 2019-10-11 Last updated: 2019-10-11

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