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A study of neural activity and functional connectivity within the olfactory brain network in Parkinsons disease
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
Ctr Imagerie Rive Droite SA, Switzerland; Uppsala Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology in Linköping.
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2019 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 23, article id UNSP 101946Article in journal (Refereed) Published
Abstract [en]

Olfactory dysfunction is an early manifestation of Parkinsons disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls in terms of neural activity and functional connectivity within the olfactory brain network. Twenty PD patients and twenty healthy controls were examined with olfactory fMRI and resting-state fMRI. Data analysis of olfactory fMRI included data-driven tensorial independent component (ICA) and task-driven general linear model (GLM) analyses. Data analysis of resting-state fMRI included probabilistic ICA based on temporal concatenation and functional connectivity analysis within the olfactory network. ICA of olfactory fMRI identified an olfactory network consisting of the posterior piriform cortex, insula, right orbitofrontal cortex and thalamus. Recruitment of this network was less significant for PD patients. GLM analysis revealed significantly lower activity in the insula bilaterally and the right orbitofrontal cortex in PD compared to healthy controls but no significant differences in the olfactory cortex itself. Analysis of resting-state fMRI did not reveal any differences in the functional connectivity within the olfactory, default mode, salience or central executive networks between the two groups. In conclusion, olfactory dysfunction in PD is associated with less significant recruitment of the olfactory brain network. ICA could demonstrate differences in both the olfactory cortex and its main projections, compared to GLM that revealed differences only on the latter. Resting-state fMRI did not reveal any significant differences in functional connectivity within the olfactory, default mode, salience and central executive networks in this cohort.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 23, article id UNSP 101946
Keywords [en]
fMRI; Parkinson; Olfaction; Functional connectivity
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-161224DOI: 10.1016/j.nicl.2019.101946ISI: 000485804400125PubMedID: 31491835OAI: oai:DiVA.org:liu-161224DiVA, id: diva2:1365160
Note

Funding Agencies|Swedish Parkinson Foundation; Linkoping University Hospital Research Fund; ALF Grants from Region Ostergotland

Available from: 2019-10-23 Created: 2019-10-23 Last updated: 2019-10-30

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Georgiopoulos, CharalamposWitt, SuzanneDizdar Segrell, NilZachrisson, HeleneEngström, Maria
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Division of Neuro and Inflammation ScienceDepartment of Neurology in LinköpingDivision of Cardiovascular MedicineDepartment of Clinical Physiology in Linköping
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