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Immunomodulators: Friends or Enemies in Surgery for Crohns Disease?
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Cty Hosp, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.ORCID iD: 0000-0001-7518-9213
2019 (English)In: Current Drug Targets, ISSN 1389-4501, E-ISSN 1873-5592, Vol. 20, no 13, p. 1384-1398Article, review/survey (Refereed) Published
Abstract [en]

Crohns disease may severely impact the quality of life and being a chronic disease it requires both medical and surgical treatment aimed at induction and maintenance of remission to prevent relapsing symptoms and the need for further surgery. Surgery in Crohns disease often has to be performed in patients with well-known risk factors of post-operative complications, particularly intra-abdominal septic complications. This review will look at the current knowledge of immunomodulating therapies in the peri-operative phase of Crohns disease. The influence of immunomodulators on postoperative complications is evaluated by reviewing available clinical reports and data from animal studies. Furthermore, the effect of immunomodulators on preventing or deferring primary as well as repeat surgery in Crohns disease is reviewed with particular consideration given to high-risk cohorts and timing of prophylaxis.

Place, publisher, year, edition, pages
BENTHAM SCIENCE PUBL LTD , 2019. Vol. 20, no 13, p. 1384-1398
Keywords [en]
Crohns disease; inflammatory bowel disease; surgery; immunomodulators; thiopurines; azathioprine; mercaptopurine
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-161226DOI: 10.2174/1389450120666190617163919ISI: 000485783300011PubMedID: 31237212OAI: oai:DiVA.org:liu-161226DiVA, id: diva2:1365330
Available from: 2019-10-24 Created: 2019-10-24 Last updated: 2019-10-24

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Landerholm, KalleKalman, Thordis DisaWallon, ConnyMyrelid, Pär
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Surgery in Linköping
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