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Structural anomaly in the reticular formation in narcolepsy type 1, suggesting lower levels of neuromelanin
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University.
Univ Gothenburg, Sweden.
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2019 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 23, article id 101875Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate structural changes in the brain stem of adolescents with narcolepsy, a disorder characterized by excessive daytime sleepiness, fragmented night-time sleep, and cataplexy. For this purpose, we used quantitative magnetic resonance imaging to obtain R1 and R2 relaxation rates, proton density, and myelin maps in adolescents with narcolepsy (n = 14) and healthy controls (n = 14). We also acquired resting state functional magnetic resonance imaging (fMRI) for brainstem connectivity analysis. We found a significantly lower R2 in the rostral reticular formation near the superior cerebellar peduncle in narcolepsy patients, family wise error corrected p = .010. Narcolepsy patients had a mean R2 value of 1.17 s(-1) whereas healthy controls had a mean R2 of 1.31 s(-1), which was a large effect size with Cohen d = 4.14. We did not observe any significant differences in R1 relaxation, proton density, or myelin content. The sensitivity of R2 to metal ions in tissue and the transition metal ion chelating property of neuromelanin indicate that the R2 deviant area is one of the neuromelanin containing nuclei of the brain stem. The close proximity and its demonstrated involvement in sleep-maintenance, specifically through orexin projections from the hypothalamus regulating sleep stability, as well as the results from the connectivity analysis, suggest that the observed deviant area could be the locus coeruleus or other neuromelanin containing nuclei in the proximity of the superior cerebellar peduncle. Hypothetically, the R2 differences described in this paper could be due to lower levels of neuromelanin in this area of narcolepsy patients.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 23, article id 101875
Keywords [en]
Quantitative MRI (qMRI); Relaxation time; Myelin; Neuromelanin; Orexin/hypocretin; Locus coeruleus
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-161223DOI: 10.1016/j.nicl.2019.101875ISI: 000485804400070PubMedID: 31174102Scopus ID: 2-s2.0-85066452803OAI: oai:DiVA.org:liu-161223DiVA, id: diva2:1365644
Note

Funding Agencies|Research Council of South East Sweden [FORSS-480551]; Knut and Alice Wallenberg foundationKnut & Alice Wallenberg Foundation [KAW 2013.0076]; Country council of Ostergotland, Sweden [LIO-304651]

Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-12-09Bibliographically approved

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Morales Drissi, NatashaWarntjes, Marcel Jan BertusWessen, AlexanderLandtblom, Anne-MarieGauffin, HelenaEngström, Maria
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Division of Radiological SciencesFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Division of Cardiovascular MedicineDepartment of Clinical Physiology in LinköpingLinköping UniversityDivision of Neuro and Inflammation ScienceDepartment of Neurology in Linköping
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