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Validation of speed-resolved laser Doppler perfusion in a multimodal optical system using a blood-flow phantom
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0003-4377-8544
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Perimed AB, Sweden.ORCID iD: 0000-0002-3454-6576
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-6385-6760
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
2019 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 24, no 9, article id 095002Article in journal (Refereed) Published
Abstract [en]

The PeriFlux 6000 EPOS system combines diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) for the assessment of oxygen saturation (expressed in percentage), red blood cell (RBC) tissue fraction (expressed as volume fraction, %RBC), and perfusion (%RBC x mm/s) in the microcirculation. It also allows the possibility of separating the perfusion into three speed regions (0 to 1, 1 to 10, and amp;gt;10 mm/s). We evaluate the speed-resolved perfusion components, i.e., the relative amount of perfusion within each speed region, using a blood-flow phantom. Human blood was pumped through microtubes with an inner diameter of 0.15 mm. Measured DRS and LDF spectra were compared to Monte Carlo-simulated spectra in an optimization routine, giving the best-fit parameters describing the measured spectra. The root-mean-square error for each of the three speed components (0 to 1, 1 to 10, and amp;gt;10 mm/s, respectively) when describing the blood-flow speed in the microtubes was 2.9%, 8.1%, and 7.7%. The presented results show that the system can accurately discriminate blood perfusion originating from different blood-flow speeds, which may enable improved measurement of healthy and dysfunctional microcirculatory flow. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.

Place, publisher, year, edition, pages
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS , 2019. Vol. 24, no 9, article id 095002
Keywords [en]
laser Doppler; perfusion; blood flow; phantom
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-161173DOI: 10.1117/1.JBO.24.9.095002ISI: 000489022800003PubMedID: 31512441OAI: oai:DiVA.org:liu-161173DiVA, id: diva2:1365722
Note

Funding Agencies|Swedens innovation agency VINNOVAvia the program MedTech4Health [2016-02211]

Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-10-25

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Jonasson, HannaFredriksson, IngemarLarsson, MarcusStrömberg, Tomas
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