There exist different types or genres of design science research(DSR) in information systems, like laboratory-oriented and practice-orientedDSR. This paper investigates arguments for a practice-oriented approach toDSR. It uses the research approach of practice research as a starting point toelaborate on a practice-oriented DSR approach we label Practice DesignResearch (PDR). In doing so, we address two unresolved issues in IS DSR:Theorizing and evaluation. PDR consists of two inter-related sub-activities:theorizing and situational design inquiry. The conduct of situational designinquiry is described as iterative cycles of (1) pre-evaluate, (2) plan & design,(3) test & intervene and (4) post-evaluate. We justify the foundations of theseiterative sub-activities/cycles through a theoretically informed argument basedon pragmatist philosophy and practice theory.