liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals
China Agr Univ, Peoples R China; Hunan Agr Univ, Peoples R China.
Shandong Acad Clin Med, Peoples R China.
China Agr Univ, Peoples R China.
Shandong Ctr Dis Control and Prevent, Peoples R China.
Show others and affiliations
2019 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 127, no 10, article id 107009Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES: We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China. METHODS: We conducted a comprehensive sampling strategy in 12 villages in Shandong, China. Using the household [residents and their backyard animals (farm and companion animals)] as a single surveillance unit, we assessed the prevalence of CRE at the household level and examined the factors associated with CRE carriage through a detailed questionnaire. Genetic relationships among human- and animal-derived CRE were assessed using whole-genome sequencing-based molecular methods. RESULTS: A total of 88 New Delhi metallo-beta-lactamases-type carbapenem-resistant Escherichia coli (NDM-EC), including 17 from humans, 44 from pigs, 12 from chickens, 1 from cattle, and 2 from dogs, were isolated from 65 of the 746 households examined. The remaining 12 NDM-EC were from flies in the immediate backyard environment. The NDM-EC colonization in households was significantly associated with a) the number of species of backyard animals raised/kept in the same household, and b) the use of human and/or animal feces as fertilizer. Discriminant analysis of principal components (DAPC) revealed that a large proportion of the core genomes of the NDM-EC belonged to strains from hosts other than their own, and several human isolates shared closely related core single-nucleotide polymorphisms and bla(NDM)( )genetic contexts with isolates from backyard animals. CONCLUSIONS: To our knowledge, we are the first to report evidence of direct transmission of NDM-EC between humans and animals. Given the rise of NDM-EC in community and hospital infections, combating NDM-EC transmission in backyard farm systems is needed.

Place, publisher, year, edition, pages
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE , 2019. Vol. 127, no 10, article id 107009
National Category
Other Biological Topics
Identifiers
URN: urn:nbn:se:liu:diva-162352DOI: 10.1289/EHP5251ISI: 000492748900009PubMedID: 31642700OAI: oai:DiVA.org:liu-162352DiVA, id: diva2:1374026
Note

Funding Agencies|National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81361138021, 81861138051, 81661138002]; National Key Research and Development Program of China [2018YFD0500300]; Swedish Research CouncilSwedish Research Council [D0879801]; Medical Research CouncilMedical Research Council UK (MRC) [MR/P007295/1]

Available from: 2019-11-28 Created: 2019-11-28 Last updated: 2019-11-28

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nilsson, Lennart EBörjesson, Stefan
By organisation
Division of Microbiology, Infection and InflammationFaculty of Medicine and Health Sciences
In the same journal
Journal of Environmental Health Perspectives
Other Biological Topics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf