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Celiac disease and complement activation in response to Streptococcus pneumoniae
Kalmar Cty Hosp, Sweden; Orebro Univ, Sweden.
Kalmar Cty Hosp, Sweden.
Linnaeus Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences. Kalmar Cty Hosp, Sweden.
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2019 (English)In: European Journal of Pediatrics, ISSN 0340-6199, E-ISSN 1432-1076Article in journal (Refereed) Epub ahead of print
Abstract [en]

Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999-2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively). Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.

Place, publisher, year, edition, pages
SPRINGER , 2019.
Keywords [en]
Coeliac; Pneumococcal; Infection; Innate immunity; MBL
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-162327DOI: 10.1007/s00431-019-03490-wISI: 000494392200001PubMedID: 31691001OAI: oai:DiVA.org:liu-162327DiVA, id: diva2:1374033
Note

Funding Agencies|Medical Research Council of Southeast Sweden [658741]; Region Kalmar County; Swedish Research CouncilSwedish Research Council [522-2A09-195, 2016-2075-5.1, 2018-04087]; Swedish Celiac Society; Fulbright Commission; Linnaeus University; Norwegian Research CouncilResearch Council of Norway [274332]; Orebro University

Available from: 2019-11-28 Created: 2019-11-28 Last updated: 2020-01-15

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