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Effect of N-G-monomethyl l-arginine on microvascular blood flow and glucose metabolism after an oral glucose load
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Åby.ORCID iD: 0000-0002-4245-7565
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
2019 (English)In: Microcirculation, ISSN 1073-9688, E-ISSN 1549-8719, article id e12597Article in journal (Refereed) Epub ahead of print
Abstract [en]

Objective The aim of this study was to investigate whether the effects on local blood flow and metabolic changes observed in the skin after an endogenous systemic increase in insulin are mediated by the endothelial nitric oxide pathway, by administering the nitric oxide synthase inhibitor N-G-monomethyl l-arginine using microdialysis. Methods Microdialysis catheters, perfused with N-G-monomethyl l-arginine and with a control solution, were inserted intracutaneously in 12 human subjects, who received an oral glucose load to induce a systemic hyperinsulinemia. During microdialysis, the local blood flow was measured by urea clearance and by laser speckle contrast imaging, and glucose metabolites were measured. Results After oral glucose intake, microvascular blood flow and glucose metabolism were both significantly suppressed in the N-G-monomethyl l-arginine catheter compared to the control catheter (urea clearance: P amp;lt; .006, glucose dialysate concentration: P amp;lt; .035). No significant effect of N-G-monomethyl l-arginine on microvascular blood flow was observed with laser speckle contrast imaging (P = .81). Conclusion Local delivery of N-G-monomethyl l-arginine to the skin by microdialysis reduces microvascular blood flow and glucose delivery in the skin after oral glucose intake, presumably by decreasing local insulin-mediated vasodilation.

Place, publisher, year, edition, pages
WILEY , 2019. article id e12597
Keywords [en]
insulin; l-NMMA; metabolism; microcirculation; microdialysis
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-162323DOI: 10.1111/micc.12597ISI: 000494847400001PubMedID: 31628700OAI: oai:DiVA.org:liu-162323DiVA, id: diva2:1374034
Note

Funding Agencies|ALF grants, Region Ostergotland, Linkoping, Sweden

Available from: 2019-11-28 Created: 2019-11-28 Last updated: 2019-11-28

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Högstedt, AlexandraIredahl, FredrikTesselaar, ErikFarnebo, Simon
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesPrimary Health Care Center ÅbyDepartment of Hand and Plastic Surgery
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Microcirculation
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