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Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden.
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2013 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 35, no 1-2, p. 67-76Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/AIMS: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort.

METHODS: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT).

RESULTS: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance.

CONCLUSION: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.

Place, publisher, year, edition, pages
S. Karger, 2013. Vol. 35, no 1-2, p. 67-76
National Category
Neurology Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-162662DOI: 10.1159/000346292PubMedID: 23364030OAI: oai:DiVA.org:liu-162662DiVA, id: diva2:1377943
Available from: 2019-12-13 Created: 2019-12-13 Last updated: 2021-04-30Bibliographically approved

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