Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up.Show others and affiliations
2013 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 35, no 1-2, p. 67-76Article in journal (Refereed) Published
Abstract [en]
BACKGROUND/AIMS: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort.
METHODS: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT).
RESULTS: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance.
CONCLUSION: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.
Place, publisher, year, edition, pages
S. Karger, 2013. Vol. 35, no 1-2, p. 67-76
National Category
Neurology Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-162662DOI: 10.1159/000346292PubMedID: 23364030OAI: oai:DiVA.org:liu-162662DiVA, id: diva2:1377943
2019-12-132019-12-132021-04-30Bibliographically approved