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Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease
Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.
Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.
The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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2014 (English)In: Alzheimer's Research & Therapy, E-ISSN 1758-9193, Alzheimer's research & therapy, ISSN 1758-9193, Vol. 6, no 3, article id 25Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD), compared with age-matched controls.

METHODS: In total, 247 CSF samples were assessed in this study, including 71 patients with DLB, 30 patients with PDD, 48 patients with AD, and 98 healthy age-matched controls. Both total and oligomeric α-synuclein levels were evaluated by using well-established immunoassays.

RESULTS: The levels of α-synuclein oligomers in the CSF were increased in patients with PDD compared with the controls (P < 0.05), but not in patients with DLB compared with controls. Interestingly, the levels of α-synuclein oligomers in the CSF were also significantly higher in patients with PDD (P < 0.01) and DLB (P < 0.05) compared with patients with AD. The levels of CSF α-synuclein oligomers and the ratio of oligomeric/total-α-synuclein could distinguish DLB or PDD patients from AD patients, with areas under the curves (AUCs) of 0.64 and 0.75, respectively. In addition, total-α-synuclein alone could distinguish DLB or PDD patients from AD patients, with an AUC of 0.80.

CONCLUSIONS: The levels of α-synuclein oligomers were increased in the CSF from α-synucleinopathy patients with dementia compared with AD cases.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 6, no 3, article id 25
National Category
Neurology Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-162686DOI: 10.1186/alzrt255ISI: 000343200100002PubMedID: 24987465Scopus ID: 2-s2.0-84989182833OAI: oai:DiVA.org:liu-162686DiVA, id: diva2:1379215
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2020-01-22Bibliographically approved

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Nägga, Katarina

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