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Increased levels of hyaluronic acid in cerebrospinal fluid in patients with vascular dementia
Lund University, Malmö, Sweden.ORCID iD: 0000-0003-0194-8402
Lund University, Malmö, Sweden.
Lund University, Malmö, Sweden; Skåne University Health Care Lund, Lund, Sweden.
Lund University, Malmö, Sweden.
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2014 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 42, no 4, p. 1435-1441Article in journal (Refereed) Published
Abstract [en]

Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as a clinical diagnostic biomarker to identify vascular pathology in dementia, we analyzed the levels of HA in the CSF of patients with vascular dementia (VaD) (n = 46), AD (n = 45), and controls without dementia (n = 26). In line with our previous data, we found significantly increased levels of HA in CSF from patients with VaD compared with controls, whereas the levels of HA in patients with AD were found to be unaltered compared with controls and patients with VaD. We also detected increased levels of HA in individuals with vascular changes determined as significant white matter changes or previous infarction on cranial computed tomography or magnetic resonance imaging, compared with individuals without these findings. Furthermore, we found a significant positive correlation between the levels of HA and the CSF/serum albumin ratio, an indicator of blood-brain barrier integrity, in patients with VaD and AD, supporting the role of HA in vascular changes in the brain. Our results indicate a potential diagnostic value for the detection of vascular brain changes in dementia using CSF levels of HA, but emphasize the importance of further development of more sensitive HA assays.

Place, publisher, year, edition, pages
IOS Press, 2014. Vol. 42, no 4, p. 1435-1441
Keywords [en]
Biomarker, cerebrospinal fluid, glycocalyx, hyaluronic acid, vascular dementia
National Category
Neurology Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-162687DOI: 10.3233/JAD-141200ISI: 000343763000028PubMedID: 25024336Scopus ID: 2-s2.0-84907972736OAI: oai:DiVA.org:liu-162687DiVA, id: diva2:1379217
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2020-01-07Bibliographically approved

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Nägga, Katarina

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