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Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients
Lund University, Malmö, Sweden.
Lund University, Malmö, Sweden.
Lund University, Malmö, Sweden.ORCID iD: katarina.nagga@med.lu.se
Lund University, Malmö, Sweden.
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2015 (English)In: Alzheimer's Research & Therapy, E-ISSN 1758-9193, Alzheimer's research & therapy, ISSN 1758-9193, Vol. 7, no 1, article id 63Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.

METHODS: To analyse CSF of patients with AD (n = 45), patients with DLB (n = 29) and control subjects without dementia (n = 36), we used immunoassays to measure levels of IL-6 (multiplex electrochemiluminescence); AD markers phosphorylated tau, total tau and amyloid-β1-42 (enzyme-linked immunosorbent assay [ELISA]); and α-synuclein (ELISA). Cognitive status was evaluated using the Mini Mental State Examination (MMSE).

RESULTS: Our analysis showed significantly lower levels of IL-6 in CSF from patients with DLB than in CSF from patients with AD and control subjects without dementia. The IL-6 levels were also negatively correlated with MMSE and positively correlated with α-synuclein CSF levels.

CONCLUSIONS: Our findings support previous studies by demonstrating a link between inflammatory processes and dementia progression and further strengthen the hypothesis that IL-6 is involved in dementia pathology and cognitive decline.

Place, publisher, year, edition, pages
BioMed Central, 2015. Vol. 7, no 1, article id 63
National Category
Geriatrics Neurology
Identifiers
URN: urn:nbn:se:liu:diva-162693DOI: 10.1186/s13195-015-0145-yISI: 000362245500001PubMedID: 26434635Scopus ID: 2-s2.0-84942940978OAI: oai:DiVA.org:liu-162693DiVA, id: diva2:1379233
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2020-01-08Bibliographically approved

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