liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Characterization of the gamma delta T-cell compartment during infancy reveals clear differences between the early neonatal period and 2 years of age
Stockholm Univ, Sweden.
Stockholm Univ, Sweden.
Stockholm Univ, Sweden.
Stockholm Univ, Sweden.
Show others and affiliations
(English)In: Immunology and Cell Biology, ISSN 0818-9641, E-ISSN 1440-1711Article in journal (Refereed) Epub ahead of print
Abstract [en]

gamma delta T cells are unconventional T cells that function on the border of innate and adaptive immunity. They are suggested to play important roles in neonatal and infant immunity, although their phenotype and function are not fully characterized in early childhood. We aimed to investigate gamma delta T cells in relation to age, prematurity and cytomegalovirus (CMV) infection. Therefore, we used flow cytometry to characterize the gamma delta T-cell compartment in cord blood and peripheral blood cells from 14-day-, 2-year- and 5-year-old children, as well as in peripheral blood samples collected at several time points during the first months of life from extremely premature neonates. gamma delta T cells were phenotypically similar at 2 and 5 years of age, whereas cord blood was divergent and showed close proximity to gamma delta T cells from 14-day-old neonates. Interestingly, 2-year-old children and adults showed comparable V delta 2(+) gamma delta T-cell functionality toward both microbial and polyclonal stimulations. Importantly, extreme preterm birth compromised the frequencies of V delta 1(+) cells and affected the functionality of V delta 2(+) gamma delta T cells shortly after birth. In addition, CMV infection was associated with terminal differentiation of the V delta 1(+) compartment at 2 years of age. Our results show an adult-like functionality of the gamma delta T-cell compartment already at 2 years of age. In addition, we demonstrate an altered gamma delta T-cell phenotype early after birth in extremely premature neonates, something which could possible contribute to the enhanced risk for infections in this vulnerable group of children.

Place, publisher, year, edition, pages
WILEY.
Keywords [en]
childhood immunity; CMV; cord blood; neonatal immunity; prematurity; gamma delta T cells
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-162732DOI: 10.1111/imcb.12303ISI: 000499694100001PubMedID: 31680329OAI: oai:DiVA.org:liu-162732DiVA, id: diva2:1380724
Note

Funding Agencies|Swedish Research CouncilSwedish Research Council [2016-01715_3]; Torsten Soderberg Foundation; Cancer and Allergy Foundation; Swedish Asthma and Allergy Associations Research Foundation; Hesselman Foundation; Golden Jubilee Memorial Foundation; Crownprincess Lovisa/Axel Tielman Foundations; Engkvist Foundations; Swedish Heart-Lung FoundationSwedish Heart-Lung Foundation; Hedlund Foundation

Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2020-01-22

Open Access in DiVA

fulltext(773 kB)6 downloads
File information
File name FULLTEXT01.pdfFile size 773 kBChecksum SHA-512
876f2a2cca69e111c3c71f6dc92a8a85266a1c6345f9f2d31a4a3662fc3df7966c3e3dfffa3b376e8fcc31fa53c46627b6c28a9ed657b16efd25f90d056b2eb1
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jenmalm, MariaAbrahamsson, Thomas
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Children's and Women's healthH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala
In the same journal
Immunology and Cell Biology
Immunology

Search outside of DiVA

GoogleGoogle Scholar
Total: 6 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 13 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf