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Allergy development is associated with consumption of breastmilk with a reduced microbial richness in the first month of life
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Inst Agrochem and Food Technol IATA CSIC, Spain; FISABIO, Spain.
FISABIO, Spain; CIBER ESP, Spain.
FISABIO, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
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2019 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background Early colonization with a diverse microbiota seems to play a crucial role for appropriate immune maturation during childhood. Breastmilk microbiota is one important source of microbes for the infant, transferred together with maternal IgA antibodies. We previously observed that allergy development during childhood was associated with aberrant IgA responses to the gut microbiota already at 1 month of age, when the IgA antibodies are predominantly maternally derived in breastfed infants. Objective To determine the microbial composition and IgA-coated bacteria in breastmilk in relation to allergy development in children participating in an intervention trial with pre- and post-natal Lactobacillus reuteri supplementation. Methods A combination of flow cytometric cell sorting and 16S rRNA gene sequencing was used to characterize the bacterial recognition patterns by IgA in breastmilk samples collected one month post-partum from 40 mothers whose children did or did not develop allergic and asthmatic symptoms during the first 7 years of age. Results The milk fed to children developing allergic manifestations had significantly lower bacterial richness, when compared to the milk given to children that remained healthy. Probiotic treatment influenced the breastmilk microbiota composition. However, the proportions of IgA-coated bacteria, the total bacterial load and the patterns of IgA-coating were similar in breastmilk between mothers of healthy children and those developing allergies. Conclusion Consumption of breastmilk with a reduced microbial richness in the first month of life may play an important role in allergy development during childhood.

Place, publisher, year, edition, pages
WILEY , 2019.
Keywords [en]
allergy; breastmilk; IgA; microbiota; mother-infant transfer
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-162862DOI: 10.1111/pai.13176ISI: 000501885300001PubMedID: 31736150OAI: oai:DiVA.org:liu-162862DiVA, id: diva2:1382278
Note

Funding Agencies|Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]; Swedish Research CouncilSwedish Research Council [2016-01698]; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation [20140321, 20170365]; Cancer and Allergy Foundation; European Research Council (ERC)European Research Council (ERC)Estonian Research Council [639226]

Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-02-27

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The full text will be freely available from 2020-11-17 15:18
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Dzidic, MajdaAbrahamsson, ThomasJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Children's and Women's healthH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala
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