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Survival after intensive care for COPD exacerbation in patients with and without long-term oxygen therapy: a nationwide cohort study
Department of Surgical and Perioperative Sciences, Anaesthesiology and Intensive Care Medicine, Umeå University, Umeå, Sweden.
Department of Anaesthesia and Intensive Care, Västervik Hospital, Västervik, Sweden.
Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.
Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, no Suppl 63Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Current knowledge about prognosis after intensive care for COPD exacerbation in patients with long-term oxygen therapy (LTOT) is limited.

Aims: To investigate survival after ICU admission for COPD exacerbation in patients with and without LTOT.

Material and methods: Nationwide observational cohort study including all first-time ICU admissions for COPD exacerbation in the Swedish Intensive Care Register 2008-2015. The National Quality Register for Respiratory Failure (Swedevox) provided data on LTOT. Mortality was traced through the Population Register.

Results: The cohort included 4828 patients (60% women) and 466 had LTOT before first ICU admission. LTOT patients were older (median 74 years (IQR 69-79) vs 72 years (IQR 66-78), p<0.001) and had higher simplified acute physiology score 3 (SAPS3) score; median 60 (IQR 54-68) vs 59 (IQR 52-66), p=0.008).

Mortality was higher for LTOT patients in the ICU (13.5% vs 7.5%; p<0.001) and at 30 days after ICU admission (37.8% vs 25.0%; p<0.001). In logistic regression adjusted for SAPS3 score and sex, LTOT was associated with increased 30-day mortality (OR 1.8; 95% CI 1.4-2.2).Median survival time from ICU admission was 3.2 months (IQR 0.2-17.7) for LTOT patients and 16.0 months (IQR 1.0-52.8) for patients without LTOT.

Place, publisher, year, edition, pages
European Respiratory Society , 2019. Vol. 54, no Suppl 63
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-163273DOI: 10.1183/13993003.congress-2019.PA2184OAI: oai:DiVA.org:liu-163273DiVA, id: diva2:1388118
Conference
ERS International Congress 2019, Madrid, Spain, 28 September-2 October
Available from: 2020-01-23 Created: 2020-01-23 Last updated: 2020-01-23

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Walther, Sten

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