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World apheresis registry 2003-2007 data
University Hospital, Umeå.
Czech Republic .
University Hospital, Uppsala.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
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2008 (English)In: Transfusion and apheresis science, ISSN 1473-0502, Vol. 39, no 3, 247-254 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Seventy-five centers from many countries have applied for a login code to the WAA apheresis registry. Fifteen centers from 7 countries have been actively entering data at the internet site from 2003 until 2007. We report on data from the registry so far.

Methods: This is a web-based registry. A link is available from the WAA homepage ( So far data from 2013 patients (12,448 procedures) have been included. A median of 6 treatments have been performed (range 1140). Mean age 51 years (range 1-94 years; 45% women). Seven percent of the patients were <= 21 years and 4% were <= 16 years.

Results: The purpose of the apheresis procedure was therapeutic in 67% and retrieval of blood components in 33% Main indications: neurological and hematological diseases, lipid apheresis and stemcell collection (autologous, and some allogeneic). Blood access: peripheral vessels (71%), central dialysis catheter through jugular (6.5%) or subclavian veins (6.7%), femoral vein (8%) and AV fistula (4%). ACD was used for anticoagulation in 73% of the procedures. Albumin was mainly used as replacement fluid.

Adverse events (AE) were registered in 5.7% of the procedures. AE was graded as mild (2.5%), moderate (2.7%) or severe (0.5%). No death occurred due to treatment. The procedures were interrupted in 2.6%. Most frequent AEs were blood access problems (29%), tingling around the mouth (20%), hypotension (18%), and urticaria (9%). There were significant differences between the centers regarding mild and moderate AEs. Data indicate that centers using continuous infusion of calcium had fewer AEs.

Conclusion: There was a limited number of severe AEs. Centers use various standard procedures for apheresis. By learning from the experience of others the treatment quality will improve further. In the near future, an update of the registry will enable more extensive evaluation of the data.

Place, publisher, year, edition, pages
2008. Vol. 39, no 3, 247-254 p.
Keyword [en]
Apheresis, Registry, Quality assurance, Adverse event, Side effects, Plasma exchange, Stem cell collection
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16400DOI: 10.1016/j.transci.2008.09.003OAI: diva2:139516
Available from: 2009-01-23 Created: 2009-01-23 Last updated: 2009-08-21

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Berlin, Gösta
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Department of Clinical and Experimental MedicineFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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