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Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL. (Landstinget i Östergötland)
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences.
2008 (English)In: APMIS, ISSN 0903-4641, Vol. 116, no 12, 1082-1088 p.Article in journal (Refereed) Published
Abstract [en]

Chlamydia pneumoniae has during recent years been associated with cardiovascular disease and atherosclerosis. Chemokines, leukocyte adhesion proteins and metalloproteinases are significant for chemotaxis and attachment of leukocytes to vessel walls, and for stability of atherosclerotic plaques. To determine the ability of C. pneumoniae to elicit inflammation in a relevant target host cell, we infected human coronary artery endothelial cells (HCAEC) with a clinical isolate of C. pneumoniae. Extracellular release of five chemokines, two adhesion proteins and a metalloproteinase was measured at different time points after infection using a cytometric bead assay and ELISA. Secretion of IL-8, MCP-1, MIG, IP-10 and ICAM-1 was significantly increased 48 h after C. pneumoniae infection of HCAEC in comparison with uninfected controls. Release of RANTES occurred already 6 h after infection. C. pneumoniae did not elicit release of E-selectin or MMP-1. We conclude that C. pneumoniae induces expression of proinflammatory components in HCAEC, which would promote migration of leukocytes towards endothelial cells. This suggests that C. pneumoniae initiates and propagates vascular inflammation in ways that contribute to coronary artery disease.

Place, publisher, year, edition, pages
2008. Vol. 116, no 12, 1082-1088 p.
Keyword [en]
Coronary artery inflammation, C, pneumoniae, chemokines
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16422DOI: 10.1111/j.1600-0463.2008.01145.xOAI: oai:DiVA.org:liu-16422DiVA: diva2:139585
Note
The definitive version is available at www.blackwell-synergy.com:Marie Högdahl, G Söderlund and Erik Kihlström, Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae, 2008, APMIS, (116), 12, 1082-1088.http://dx.doi.org/10.1111/j.1600-0463.2008.01145.xCopyright: Blackwell Publishing Ltdhttp://www.blackwellpublishing.com/Available from: 2009-03-06 Created: 2009-01-23 Last updated: 2009-08-19Bibliographically approved

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CiteExportLink to record
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