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Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
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2019 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 160, no 11, p. 2603-2611Article in journal (Refereed) Published
Abstract [en]

Compression of the trigeminal root entry zone by a blood vessel can cause trigeminal neuralgia (TN). However, a neurovascular conflict does not explain all cases of TN, and TN can exist without a neurovascular contact. A common observation during microvascular decompression surgery to treat TN is arachnoiditis in the region of the trigeminal nerve. Thus, aberrant inflammatory mechanisms may be involved in the pathophysiology of TN but information about the role of inflammation in TN is scarce. We used Proximity Extension Assay technology to analyse the levels of 92 protein biomarkers related to inflammation in lumbar cerebrospinal fluid from patients with TN (n = 27) before and after microvascular decompression compared to individuals without TN. We aimed to analyse the pattern of inflammation-related proteins in order to improve our understanding of the pathophysiology of TN. The main finding was that immunological protein levels in the cerebrospinal fluid from patients with TN decreased after surgery towards levels observed in healthy controls. Two proteins seemed to be of specific interest for TN: TRAIL and TNF-beta. Thus, inflammatory activity might be one important mechanism in TN.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019. Vol. 160, no 11, p. 2603-2611
Keywords [en]
Trigeminal neuralgia; Microvascular decompression; Biomarkers; PEA; Inflammation
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-164063DOI: 10.1097/j.pain.0000000000001649ISI: 000512906800019PubMedID: 31373951Scopus ID: 2-s2.0-85073580086OAI: oai:DiVA.org:liu-164063DiVA, id: diva2:1410976
Note

Funding Agencies|Thureus Stiftelse; Svenska Huvudvarkssallskapet; ALF grants Region Uppsala; Strategic Funds Uppsala University Hospital; Magnus Bergvall Foundation; NEURO Sweden; ALF grants Region Ostergotland

Available from: 2020-03-02 Created: 2020-03-02 Last updated: 2020-03-09Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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Output format
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