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Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Genetic Engineering and Viral Vector Core, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Genetic Engineering and Viral Vector Core, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, Rockville, MD, USA.
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2019 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 43, no 2, p. 344-354Article in journal (Refereed) Published
Abstract [en]

Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by binding to the growth hormone secretagogue receptor (GHSR). Here, we present the development, verification, and initial characterization of a novel GHSR knockout (KO) Wistar rat model created with CRISPR genome editing.
Place, publisher, year, edition, pages
Nature Pub. Group , 2019. Vol. 43, no 2, p. 344-354
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Genetics and Genomics
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URN: urn:nbn:se:liu:diva-164750DOI: 10.1038/s41366-018-0013-5ISI: 000457698600012PubMedID: 29453460OAI: oai:DiVA.org:liu-164750DiVA, id: diva2:1421329
Available from: 2020-04-02 Created: 2020-04-02 Last updated: 2025-02-07

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Heilig, Markus

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