Incidence of myeloproliferative neoplasms - trends by subgroup and age in a population-based study in SwedenShow others and affiliations
2020 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 287, no 4, p. 448-454Article in journal (Refereed) Published
Abstract [en]
Background The reported incidence of Philadelphia-negative myeloproliferative neoplasms (MPNs) differs substantially between previous reports, likely due to true regional differences in incidence and/or variations in the quality and coverage of the cancer registers. Objective We therefore assessed MPN incidence in Sweden during recent years using prospectively collected information captured in Swedish health registers. Methods Patients with MPNs were identified through the Swedish Cancer Register and Swedish Blood Cancer Register between 2000 and 2014. Information on the Swedish population was obtained from the Human Mortality Database. Crude and age-standardized incidence rates of MPNs with 95% confidence intervals (CIs) were calculated. Results A total of 6281 MPN cases were reported to the Swedish Cancer Register and Swedish Blood Cancer Register during 2000-2014. The age-standardized, to the Swedish population in 2000, incidence for all MPNs was 4.45 (95% confidence interval [CI] 4.34-4.56)/100 000 person-years. The age-standardized incidence for polycythemia vera was 1.48 (1.42-1.54), for essential thrombocythemia 1.60 (1.53-1.66) and for primary myelofibrosis 0.52 (0.48-0.56)/100 000 person-years, respectively. The incidence rate of MPNs was substantially higher in the older compared to the younger age groups. The incidence increased during the study period, likely to do better reporting and increasing age of the general population. Conclusion The reported MPN incidences in our study, which were in the higher interval of previously published studies, are likely more accurate compared to previous reports due to the population-based setting and high level of coverage in the Swedish Cancer and Blood Cancer Registers.
Place, publisher, year, edition, pages
WILEY , 2020. Vol. 287, no 4, p. 448-454
Keywords [en]
myeloproliferative neoplasms; polycythemia vera; essential thrombocythemia; primary myelofibrosis; incidence
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-164995DOI: 10.1111/joim.13019ISI: 000520939100008PubMedID: 31927786OAI: oai:DiVA.org:liu-164995DiVA, id: diva2:1422736
Note
Funding Agencies|Karolinska InstitutetKarolinska Institutet; NCI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30 CA008748, P30 CA008748]; Stockholm County CouncilStockholm County Council; Swedish Research CouncilSwedish Research Council; Blodcancerfonden; Cancer Research Foundations of Radiumhemmet
2020-04-082020-04-082021-05-05