The aim of this study was to investigate the potential of creating an antimicrobial bandage composed of antimicrobial peptides and enzymes attached to a polysaccharide material such as a cellulose bandage. This bandage could be used for problematic wounds such as burn wounds which are prevalent to infections. Binding to cellulose was done by utilizing a carbohydrate binding domain (CBD) which was fused to an antimicrobial agent via a linker. The linker between the CBD and agent contains a thrombin site which allows the agents to be released when in contact with blood. The release mechanism of the antimicrobial agents increases the reach of the agents in addition to increasing their activity, as proven in this study. Both the CBD binding capacity and the thrombin cleavage mechanism were proven to be effective. The peptide used in this study was Pln1. The enzymes used were the bacteriophage lysins CHAP and PlyF307, where the latter additionally contains a peptide domain. Results showed that Pln1, CHAP and PlyF307 were highly effective against the gram-negative bacteria, whilst CHAP had the highest activity against gram-positive bacteria. A cellulose bandage was applied to bacterial cultures containing bound agents, simulating a bandage applied to a wound. The bandage without the addition of thrombin was found to be antibacterial, however, it showed a significant increase of antibacterial activity when thrombin was added, releasing the agent and allowing it full activity.