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Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies
Linköping University, Department of Biomedical and Clinical Sciences, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Univ Newcastle Tyne, England.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Gottfries Clin AB, Sweden.
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2020 (English)In: Frontiers in Medicine, E-ISSN 2296-858X, Vol. 7, article id 108Article in journal (Refereed) Published
Abstract [en]

Metabolic profiling studies have recently indicated dysfunctional mitochondria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This includes an impaired function of pyruvate dehydrogenase complex (PDC), possibly driven by serum factor(s), which leads to inadequate adenosine triphosphate generation and excessive lactate accumulation. A reminiscent energy blockade is likely to occur in primary biliary cholangitis (PBC), caused by anti-PDC autoantibodies, as recently proposed. PBC is associated with fatigue and post-exertional malaise, also signifying ME/CFS. We herein have investigated whether ME/CFS patients have autoreactive antibodies that could interfere with mitochondrial function. We found that only 1 of 161 examined ME/CFS patients was positive for anti-PDC, while all PBC patients (15/15) presented significant IgM, IgG, and IgA anti-PDC reactivity, as previously shown. None of fibromyalgia patients (0/14), multiple sclerosis patients (0/29), and healthy blood donors (0/44) controls showed reactivities. Anti-mitochondrial autoantibodies (inner and outer membrane) were negative in ME/CFS cohort. Anti-cardiolipin antibody levels in patients did not differ significantly from healthy blood donors. In conclusion, the impaired mitochondrial/metabolic dysfunction, observed in ME/CFS, cannot be explained by presence of circulating autoantibodies against the tested mitochondrial epitopes.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2020. Vol. 7, article id 108
Keywords [en]
myalgic encephalomyelitis; chronic fatigue syndrome; anti-pyruvate dehydrogenase complex antibodies; PDC; anti-mitochondrial autoantibodies; AMA
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-165479DOI: 10.3389/fmed.2020.00108ISI: 000526870400001PubMedID: 32296708Scopus ID: 2-s2.0-85083316140OAI: oai:DiVA.org:liu-165479DiVA, id: diva2:1428254
Note

Funding Agencies|Swedish ME Association; Solve ME/CFS; Swedish Cancer Association; Open Medicine Foundation (OMF)

Available from: 2020-05-05 Created: 2020-05-05 Last updated: 2024-01-29Bibliographically approved

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Dahle, Charlotte

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