Neurotrophic factors in cerebrospinal fluid and serum of patients with Rett syndromeShow others and affiliations
1998 (English)In: Journal of Child Neurology, ISSN 0883-0738, E-ISSN 1708-8283, Vol. 13, no 9, p. 429-433Article in journal (Refereed) Published
Abstract [en]
Rett syndrome is now considered to be a neurodevelopmental disease. Its cause is unknown, but it has been suggested that neuronal growth factors and neurotransmitters play important roles. We measured levels of brain-derived neurotropic factor and glial cell line-derived neurotrophic factor in cerebrospinal fluid, and nerve growth factor and brain-derived neurotrophic factor in serum in child and adolescent patients with Rett syndrome. Levels of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in cerebrospinal fluid were below the limit of sensitivity of the methods used. Serum levels of nerve growth factor and brain-derived neurotrophic factor did not differ from control values. In Rett syndrome, the normal serum levels of nerve growth factor together and previously reported low levels of the factor in cerebrospinal fluid indicate that the latter may reflect low levels of nerve growth factor in the central nervous system.
Place, publisher, year, edition, pages
Univ Helsinki, Hosp Children & Adolescents, Unit Child Neurol, Helsinki, Finland. Uppsala Univ, Ctr Biomed, Dept Dev Neurosci, Uppsala, Sweden. Univ Helsinki, Inst Biotechnol, Helsinki, Finland. Univ Kuopio, Childrens Hosp, Dept Child Neurol, FIN-70211 Kuopio, Finland.: Sage Publications, 1998. Vol. 13, no 9, p. 429-433
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-168013DOI: 10.1177/088307389801300903ISI: 000075512900003PubMedID: 9733288Scopus ID: 2-s2.0-0031714735OAI: oai:DiVA.org:liu-168013DiVA, id: diva2:1457427
2020-08-112020-08-112023-12-28Bibliographically approved