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The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
Linköping University. Uppsala universitet.
2004 (English)In: Journal of Cell Biology, ISSN 0021-9525, E-ISSN 1540-8140, Vol. 165, no 1, p. 27-30Article, review/survey (Refereed) Published
Abstract [en]

The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders.

Place, publisher, year, edition, pages
Uppsala Univ, Biomed Ctr, Unit Neurobiol, Dept Neurosci, S-75123 Uppsala, Sweden. Harvard Univ, Sch Med, McLean Hosp, Belmont, MA 02478 USA.: ROCKEFELLER UNIV PRESS , 2004. Vol. 165, no 1, p. 27-30
Keywords [en]
neurodegeneration, synapse function, Wallerian degeneration, polyubiquitination, monoubiquitination
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-167992DOI: 10.1083/jcb.200311091ISI: 000220880300003PubMedID: 15067020OAI: oai:DiVA.org:liu-167992DiVA, id: diva2:1457460
Available from: 2020-08-11 Created: 2020-08-11 Last updated: 2020-08-11

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