Hippocalcin protects against caspase-12-induced and age-dependent neuronal degenerationShow others and affiliations
2005 (English)In: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 28, no 1, p. 85-95Article in journal (Refereed) Published
Abstract [en]
Hippocalcin is a neuronal calcium binding protein, but its physiological function in brain is unknown. We show here that hippocampal neurons from hippocalcin-deficient mice are more vulnerable to degeneration, particularly using thapsigargin, elevating intracellular calcium. Caspase-12 was activated in neurons lacking hippocalcin, while calpain was unchanged. Neuronal viability was accompanied by endoplasmic reticulum (ER) stress and a change in the relative induction of the ER chaperone, BiP/GRP78. Neuronal apoptosis inhibitor protein (NAIP), known to interact with hippocalcin, was not altered, but hippocampal neurons from gene-deleted mice were more sensitive to excitotoxicity caused by kainic acid. In addition, an age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging. (C) 2004 Elsevier Inc. All rights reserved.
Place, publisher, year, edition, pages
Uppsala Univ, Ctr Biomed, Dept Neurosci, Neurobiol Unit, S-75123 Uppsala, Sweden. Uppsala Univ, Ctr Biomed, Dept Neurosci, Unit Physiol, S-75123 Uppsala, Sweden. Toho Univ, Sch Med, Dept Physiol, Ohta Ku, Tokyo 1438540, Japan. Minerva Med Res Inst, Biomedicum Helsinki, FIN-00290 Helsinki, Finland.: ACADEMIC PRESS INC ELSEVIER SCIENCE , 2005. Vol. 28, no 1, p. 85-95
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-167987DOI: 10.1016/j.mcn.2004.08.015ISI: 000226381400008PubMedID: 15607944OAI: oai:DiVA.org:liu-167987DiVA, id: diva2:1457464
2020-08-112020-08-112020-09-02