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Functional connectivity between the temporoparietal cortex and cerebellum in autism spectrum disorder
Princeton Neuroscience Institute; Department of Psychology, Princeton University, Princeton, NJ, USA.ORCID iD: 0000-0002-1904-5554
Princeton Neuroscience Institute; Department of Psychology, Princeton University, Princeton, NJ, USA.
Princeton Neuroscience Institute; Department of Psychology, Princeton University, Princeton, NJ, USA.
2017 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 27, no 4, p. 2617-2627Article in journal (Refereed) Published
Abstract [en]

The neural basis of autism spectrum disorder (ASD) is not yet understood. ASD is marked by social deficits and is strongly associated with cerebellar abnormalities. We studied the organization and cerebellar connectivity of the temporoparietal junction (TPJ), an area that plays a crucial role in social cognition. We applied localized independent component analysis to resting-state fMRI data from autistic and neurotypical adolescents to yield an unbiased parcellation of the bilateral TPJ into 11 independent components (ICs). A comparison between neurotypical and autistic adolescents showed that the organization of the TPJ was not significantly altered in ASD. Second, we used the time courses of the TPJ ICs as spatially unbiased “seeds” for a functional connectivity analysis applied to voxels within the cerebellum. We found that the cerebellum contained a fine-grained, lateralized map of the TPJ. The connectivity of the TPJ subdivisions with cerebellar zones showed one striking difference in ASD. The right dorsal TPJ showed markedly less connectivity with the left Crus II. Disturbed cerebellar input to this key region for cognition and multimodal integration may contribute to social deficits in ASD. The findings might also suggest that the right TPJ and/or left Crus II are potential targets for noninvasive brain stimulation therapies.

Place, publisher, year, edition, pages
Oxford University Press, 2017. Vol. 27, no 4, p. 2617-2627
Keywords [en]
cerebellar Crus II, default mode network, developmental diaschisis hypothesis, frontoparietal executive resting-state network, localized independent component analysis
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-169920DOI: 10.1093/cercor/bhw079ISI: 000399002400014PubMedID: 27073219Scopus ID: 2-s2.0-85021389128OAI: oai:DiVA.org:liu-169920DiVA, id: diva2:1470359
Available from: 2020-09-24 Created: 2020-09-24 Last updated: 2020-10-07Bibliographically approved

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Igelström, Kajsa

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CiteExportLink to record
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